Analysis of tissue and serum microRNA expression in patients with upper urinary tract urothelial cancer.

ABSTRACT:

Introduction

MicroRNAs play an important role in many human malignancies; so far, their expression remains to be studied in upper urinary tract urothelial cancer (UUTUC).

Materials and methods

The expression of eleven microRNAs (miR-10a, miR-21, miR-96, miR-135, miR-141, miR-182, miR-200b, miR-205, miR-429, miR-520b, miR-1244) formerly shown to be upregulated in urothelial bladder cancer were studied in corresponding normal and cancerous tissue samples of patients undergoing nephroureterectomy for UUTUC. Upregulated microRNAs were then measured in serum samples of patients with UUTUC and patients with non-malignant urological diseases to evaluate their potential as non-invasive biomarkers for UUTUC.

Results

MicroRNA expression allowed differentiation of normal and can

SUBMITTER: Kriebel S 

PROVIDER: S-EPMC4309610 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature