Comparison of microbiomes from different niches of upper and lower airways in children and adolescents with cystic fibrosis.

ABSTRACT: Changes in the airway microbiome may be important in the pathophysiology of chronic lung disease in patients with cystic fibrosis. However, little is known about the microbiome in early cystic fibrosis lung disease and the relationship between the microbiomes from different niches in the upper and lower airways. Therefore, in this cross-sectional study, we examined the relationship between the microbiome in the upper (nose and throat) and lower (sputum) airways from children with cystic fibrosis using next generation sequencing. Our results demonstrate a significant difference in both α and β-diversity between the nose and the two other sampling sites. The nasal microbiome was characterized by a polymicrobial community while the throat and sputum communities were less diverse and dominated

SUBMITTER: Boutin S 

PROVIDER: S-EPMC4309611 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature