The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance.

ABSTRACT:

Aims

We aimed to compare the performances of contemporary cystatin C (Cys)-based GFR equations, and the creatinine only Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for predicting gentamicin clearance.

Methods

The bias and imprecision of the CKD-EPI, CKD-EPI_Cys and creatinine-cystatin C CKD-EPI (CKD-EPI_CrCys) equations for predicting gentamicin clearances, were assessed in 260 patients treated with gentamicin during 2012-2013. The creatinine-cystatin C Berlin Initiative Study equation (BIS_CrCys) was examined in the ≥70 year subgroup. The reference gentamicin clearance was calculated using post-dose plasma concentrations.

Results

The CKD-EPI_CrCys equation had the highest percentage of estimates within 30% of the reference gentamicin clearanc

SUBMITTER: Chin PK 

PROVIDER: S-EPMC4309632 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature