Angiotensin receptor blockers and risk of dementia: cohort study in UK Clinical Practice Research Datalink.

ABSTRACT:

Aims

This was a cohort study to evaluate whether individuals exposed to angiotensin receptor blockers have a reduced risk of dementia compared with those exposed to angiotensin-converting enzyme inhibitors.

Methods

The study included new users of angiotensin receptor blockers or angiotensin-converting enzyme inhibitors (from 1995 to 2010) from UK primary care practices contributing to the Clinical Research Practice Datalink. The association between exposure to angiotensin receptor blockers and the risk of incident dementia was analysed using a Cox model, adjusting for age, sex, body mass index, diabetes, hypertension, heart failure, statin use, socioeconomic status, alcohol, smoking, number of consultations and calendar year.

Results

A total of 426 089 persons were in

SUBMITTER: Goh KL 

PROVIDER: S-EPMC4309639 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature