Multimodal optical imaging can reveal changes in microcirculation and tissue oxygenation during skin wound healing.

ABSTRACT:

Background and objective

Faster and better wound healing is a longstanding goal. Blood flow, angiogenesis, and tissue oxygenation are important parameters in evaluating the healing process. Optical microangiography (OMAG) allows 3D imaging of tissue vasculature and can provide quantitative blood flow information down to the capillary level of resolution. Dual wavelength laser speckle imaging (DW-LSI) can measure tissue oxygenation status.

Materials and methods

Cutaneous wound healing of a mouse ear model using a multimodal imaging system that combines OMAG with DWLSI was studied.

Results

A complete microvasculature map of the ear in vivo was obtained. The imaging system revealed both hemodynamic and metabolic changes during acute stage wound healing. Blood flow veloci

SUBMITTER: Wang H 

PROVIDER: S-EPMC4309647 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature