The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6.

ABSTRACT: Numerous studies by our lab and others demonstrate that epidermal growth factor receptor (EGFR) plays critical roles in primary breast cancer (BC) initiation, growth and dissemination. However, clinical trials targeting EGFR function in BC have lead to disappointing results. In the current study we sought to identify the mechanisms responsible for this disparity by investigating the function of EGFR across the continuum of the metastatic cascade. We previously established that overexpression of EGFR is sufficient for formation of in situ primary tumors by otherwise nontransformed murine mammary gland cells. Induction of epithelial-mesenchymal transition (EMT) is sufficient to drive the metastasis of these EGFR-transformed tumors. Examining growth factor receptor expression across this and

SUBMITTER: Wendt MK 

PROVIDER: S-EPMC4309683 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature