Interactions between the apolipoprotein E ε4 allele status and adverse childhood experiences on depressive symptoms in older adults.

ABSTRACT:

Background

The influence of childhood adversity on depression is modulated by genetic vulnerability. The apolipoprotein E ε4 (APOE-ε4) allele is a strong genetic risk factor for Alzheimer's disease (AD). Because late-life depressive symptoms could be a part of the preclinical course of AD, the APOE-ε4 allele may contribute to depression in old age.

Objective

The aim of this study was to evaluate whether an APOE-ε4 carrier status was associated with depressive symptoms in older adults and to detect the gene-environment interaction between APOE-ε4 status and childhood adversity in relation to depressive symptoms in old age.

Method

The participants consisted of 137 older adults (age range 50-70) without any psychiatric history or clinically significant cognitive impairme

SUBMITTER: Park S 

PROVIDER: S-EPMC4309830 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature