The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: an exploratory study.

ABSTRACT:

Background

There is a wealth of evidence detailing gray matter degeneration and loss of cognitive function over time in individuals with Huntington's disease (HD). Efforts to attenuate disease-related brain and cognitive changes have been unsuccessful to date. Multidisciplinary rehabilitation, comprising motor and cognitive intervention, has been shown to positively impact on functional capacity, depression, quality of life and some aspects of cognition in individuals with HD. This exploratory study aimed to evaluate, for the first time, whether multidisciplinary rehabilitation can slow further deterioration of disease-related brain changes and related cognitive deficits in individuals with manifest HD.

Methods

Fifteen participants who manifest HD undertook a multidisciplina

SUBMITTER: Cruickshank TM 

PROVIDER: S-EPMC4309878 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature