Weekly multimodal MRI follow-up of two multiple sclerosis active lesions presenting a transient decrease in ADC.

ABSTRACT:

Background and purpose

Blood-brain barrier disruption during the earliest phases of lesion formation in multiple sclerosis (MS) patients is commonly ascribed to perivenular inflammatory activity and is usually accompanied by increased diffusivity. Reduced diffusivity has also been shown in active lesions, albeit less frequently. This study aimed to characterize the development and natural history of contrast-enhanced lesions by weekly following five relapsing remitting (RR) MS patients.

Materials and methods

Diffusion tensor imaging (DTI), perfusion imaging, FLAIR and contrast-enhanced 3D T1-weighted MR, were weekly performed on five untreated patients recently diagnosed with RR MS.

Results

All five patients showed significant increases of the apparent diffusion coeff

SUBMITTER: Hannoun S 

PROVIDER: S-EPMC4309893 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature