Purkinje cell responses during visually and vestibularly driven smooth eye movements in mice.

ABSTRACT:

Introduction

An essential complement to molecular-genetic approaches for analyzing the function of the oculomotor circuitry in mice is an understanding of sensory and motor signal processing in the circuit. Although there has been extensive analysis of the signals carried by neurons in the oculomotor circuits of species, such as monkeys, rabbits and goldfish, relatively little in vivo physiology has been done in the oculomotor circuitry of mice. We analyzed the contribution of vestibular and nonvestibular signals to the responses of individual Purkinje cells in the cerebellar flocculus of mice.

Methods

We recorded Purkinje cells in the cerebellar flocculus of C57BL/6 mice during eye movement responses to vestibular and visual stimulation.

Results

As in other species,

SUBMITTER: Katoh A 

PROVIDER: S-EPMC4309896 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature