Adolescents with current major depressive disorder show dissimilar patterns of age-related differences in ACC and thalamus.

ABSTRACT:

Objective

There is little understanding of the neural system abnormalities subserving adolescent major depressive disorder (MDD). In a cross-sectional study we compare currently unipolar depressed with healthy adolescents to determine if group differences in grey matter volume (GMV) were influenced by age and illness severity.

Method

Structural neuroimaging was performed on 109 adolescents with current MDD and 36 healthy controls, matched for age, gender, and handedness. GMV differences were examined within the anterior cingulate cortex (ACC) and across the whole-brain. The effects of age and self-reported depressive symptoms were also examined in regions showing significant main or interaction effects.

Results

Whole-brain voxel based morphometry revealed no significa

SUBMITTER: Hagan CC 

PROVIDER: S-EPMC4309951 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature