Timing of Ibuprofen Use and Musculoskeletal Adaptations to Exercise Training in Older Adults.

ABSTRACT: Prostaglandins (PG) increase in bone in response to mechanical loading and stimulate bone formation. Inhibition of cyclooxygenase (COX), the enzyme responsible for PG synthesis, by non-steroidal anti-inflammatory drugs (NSAIDs) impairs the bone formation response to loading in animals when administered before, but not after, loading. The aim was to determine whether the timing of ibuprofen use (400 mg before versus after exercise sessions) is a significant determinant of the adaptive response of BMD to exercise training in older adults. We hypothesized that taking ibuprofen before exercise would attenuate the improvements in total hip and lumbar spine BMD in response to 36 weeks of training when compared with placebo or with ibuprofen use after exercise. Untrained women and men (N=189) age

SUBMITTER: Jankowski CM 

PROVIDER: S-EPMC4310009 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature