Artificial micromotors in the mouse's stomach: a step toward in vivo use of synthetic motors.

ABSTRACT: Artificial micromotors, operating on locally supplied fuels and performing complex tasks, offer great potential for diverse biomedical applications, including autonomous delivery and release of therapeutic payloads and cell manipulation. Various types of synthetic motors, utilizing different propulsion mechanisms, have been fabricated to operate in biological matrices. However, the performance of these man-made motors has been tested exclusively under in vitro conditions (outside the body); their behavior and functionalities in an in vivo environment (inside the body) remain unknown. Herein, we report an in vivo study of artificial micromotors in a living organism using a mouse model. Such in vivo evaluation examines the distribution, retention, cargo delivery, and acute toxicity profile o

SUBMITTER: Gao W 

PROVIDER: S-EPMC4310033 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature