Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial.

ABSTRACT:

Introduction

In septic shock, pulse pressure or cardiac output variation during passive leg raising are preload dependence indices reliable at predicting fluid responsiveness. Therefore, they may help to identify those patients who need intravascular volume expansion, while avoiding unnecessary fluid administration in the other patients. However, whether their use improves septic shock prognosis remains unknown. The aim of this study was to assess the clinical benefits of using preload dependence indices to titrate intravascular fluids during septic shock.

Methods

In a single-center randomized controlled trial, 60 septic shock patients were allocated to preload dependence indices-guided (preload dependence group) or central venous pressure-guided (control group) intravascula

SUBMITTER: Richard JC 

PROVIDER: S-EPMC4310180 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature