Plasma phospholipid fatty acid biomarkers of dietary fat quality and endogenous metabolism predict coronary heart disease risk: a nested case-control study within the Women's Health Initiative observational study.

ABSTRACT: Although the relationship between dietary fat quality and coronary heart disease (CHD) risk has been evaluated, typically using diet questionnaires, results are inconsistent and data in postmenopausal women are limited. Plasma phospholipid fatty acid (PL-FA) profiles, reflecting dietary intake and endogenous FA metabolism, may better predict diet-CHD risk. Using a nested case-control design, we assessed the association between plasma PL-FA profiles and CHD risk in 2448 postmenopausal women (1224 cases with confirmed CHD and 1224 controls matched for age, enrollment date, race/ethnicity, and absence of CHD at baseline and after 4.5 years of follow-up) participating in the Women's Health Initiative observational study. PL-FA profile was measured using gas chromatography. Product/precursor ra

SUBMITTER: Matthan NR 

PROVIDER: S-EPMC4310362 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature