Combining functional and tubular damage biomarkers improves diagnostic precision for acute kidney injury after cardiac surgery.

ABSTRACT:

Background

Increases in serum creatinine (ΔSCr) from baseline signify acute kidney injury (AKI) but offer little granular information regarding its characteristics. The 10th Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) suggested that combining AKI biomarkers would provide better precision for AKI course prognostication.

Objectives

This study investigated the value of combining a functional damage biomarker (plasma cystatin C [pCysC]) with a tubular damage biomarker (urine neutrophil gelatinase-associated lipocalin [uNGAL]), forming a composite biomarker for prediction of discrete characteristics of AKI.

Methods

Data from 345 children after cardiopulmonary bypass (CPB) were analyzed. Severe AKI was defined as Kidney Disease Global Outcomes Initi

SUBMITTER: Basu RK 

PROVIDER: S-EPMC4310455 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature