Development of a novel shock wave catheter ablation system--the first feasibility study in pigs.

ABSTRACT:

Introduction

Radio-frequency catheter ablation (RFCA) using Joule heat has two fundamental weaknesses: the limited depth of treatment and the risk of thrombus formation. In contrast, focused shock wave (SW) therapy could damage tissues at arbitrary depths without heat generation. Thus, we aimed to develop a SW catheter ablation (SWCA) system that could compensate for the weaknesses of RFCA therapy.

Methods and results

We developed a SWCA system where the SW generated by a Q-switched Holmium: yttrium aluminum garnet (YAG) laser beam was reflected by a reflector attached to 14-Fr catheter tip and then was converged onto the focus. We examined the feasibility of our system on pigs in vivo. When applied using the epicardial approach, the SWCA caused persistent spheroidal lesions

SUBMITTER: Hasebe Y 

PROVIDER: S-EPMC4310588 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature