Global profiling of metabolic adaptation to hypoxic stress in human glioblastoma cells.

ABSTRACT: Oncogenetic events and unique phenomena of the tumor microenvironment together induce adaptive metabolic responses that may offer new diagnostic tools and therapeutic targets of cancer. Hypoxia, or low oxygen tension, represents a well-established and universal feature of the tumor microenvironment and has been linked to increased tumor aggressiveness as well as resistance to conventional oncological treatments. Previous studies have provided important insights into hypoxia induced changes of the transcriptome and proteome; however, how this translates into changes at the metabolite level remains to be defined. Here, we have investigated dynamic, time-dependent effects of hypoxia on the cancer cell metabolome across all families of macromolecules, i.e., carbohydrate, protein, lipid and nuc

SUBMITTER: Kucharzewska P 

PROVIDER: S-EPMC4310608 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature