The rate of structural change: the confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study.

ABSTRACT:

Purpose

To compare rates of topographic change in ocular hypertensive eyes that develop primary open-angle glaucoma (POAG) compared to eyes that do not, and to identify factors that influence the rate of change.

Design

Longitudinal, randomized clinical trial.

Methods

Four hundred forty-one participants (832 eyes) in the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study were included. POAG was defined as repeatable visual field, photography-based optic disc changes, or both. The rate of topographic change in the 52 participants (66 eyes) who developed POAG was compared with that of participants who did not develop POAG using multivariable mixed effects models.

Results

In both univariate and multivariate analyses, t

SUBMITTER: Zangwill LM 

PROVIDER: S-EPMC4310682 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature