Management of patients with hormone receptor-positive breast cancer with visceral disease: challenges and treatment options.

ABSTRACT: Endocrine therapy is an important treatment option for women with hormone receptor-positive (HR+) advanced breast cancer (ABC), yet many tumors are either intrinsically resistant or develop resistance to these therapies. Treatment of patients with ABC presenting with visceral metastases, which is associated with a poor prognosis, is also problematic. There is an unmet need for effective treatments for this patient population. Although chemotherapy is commonly perceived to be more effective than endocrine therapy in managing visceral metastases, patients who are not in visceral crisis might benefit from endocrine therapy, avoiding chemotherapy-associated toxicities that might affect quality of life. To improve outcomes, several targeted therapies are being investigated in combination with e

SUBMITTER: Harb WA 

PROVIDER: S-EPMC4310719 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature