Gene interactions and structural brain change in early-onset Alzheimer's disease subjects using the pipeline environment.

ABSTRACT:

Objective

This article investigates subjects aged 55 to 65 from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to broaden our understanding of early-onset (EO) cognitive impairment using neuroimaging and genetics biomarkers.

Methods

Nine of the subjects had EO-AD (Alzheimer's disease) and 27 had EO-MCI (mild cognitive impairment). The 15 most important neuroimaging markers were extracted with the Global Shape Analysis (GSA) Pipeline workflow. The 20 most significant single nucleotide polymorphisms (SNPs) were chosen and were associated with specific neuroimaging biomarkers.

Results

We identified associations between the neuroimaging phenotypes and genotypes for a total of 36 subjects. Our results for all the subjects taken together showed the most sig

SUBMITTER: Moon SW 

PROVIDER: S-EPMC4310910 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature