Early direct and indirect impact of quadrivalent HPV (4HPV) vaccine on genital warts: a systematic review.

ABSTRACT:

Introduction

Since 2007, many countries have implemented national human papillomavirus (HPV) vaccination programs with the quadrivalent HPV (4HPV) vaccine that has been shown to be efficacious in clinical trials involving 25,000 subjects. Two vaccine serotypes, HPV16 and 18, are responsible for cervical cancer and other HPV-related cancers, but the impact of the 4HPV vaccine on these cancers cannot be seen immediately as there is a considerable lag between infection with HPV and cancer development. The other two serotypes, HPV6 and 11, are responsible for genital warts (GWs), which develop within a few months after infection, making GWs an early clinical endpoint for the assessment of the impact of 4HPV vaccination.

Methods

We performed a systematic literature search in PubM

SUBMITTER: Mariani L 

PROVIDER: S-EPMC4311067 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature