Maternal multivitamin supplementation reduces the risk of diarrhoea among HIV-exposed children through age 5 years.

ABSTRACT:

Background

The aim of this study was to determine whether maternal vitamin supplementation affects long-term mortality and morbidity of children born to HIV-infected mothers.

Methods

In total, 1078 HIV-infected pregnant woman were enrolled in a double-blind, 2×2 factorial, randomised, placebo-controlled trial in Tanzania. Data were collected for 874 children at monthly clinic visits through a median age of 51 months.

Results

Maternal receipt of multivitamins (HR=0.93; 95% CI: 0.70-1.22) or vitamin A (HR=1.00; 95% CI: 0.76-1.32) did not affect all-cause child mortality through age 5 years. Among HIV-negative children, maternal multivitamin supplementation was associated with a lower mortality rate up to 5 years (HR=0.60; 95% CI: 0.38-0.95), primarily in children <2 yea

SUBMITTER: Khavari N 

PROVIDER: S-EPMC4311151 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature