A breath fungal secondary metabolite signature to diagnose invasive aspergillosis.

ABSTRACT:

Background

Invasive aspergillosis (IA) remains a leading cause of mortality in immunocompromised patients, in part due to the difficulty of diagnosing this infection.

Methods

Using thermal desorption-gas chromatography/mass spectrometry, we characterized the in vitro volatile metabolite profile of Aspergillus fumigatus, the most common cause of IA, and other pathogenic aspergilli. We prospectively collected breath samples from patients with suspected invasive fungal pneumonia from 2011 to 2013, and assessed whether we could discriminate patients with proven or probable IA from patients without aspergillosis, as determined by European Organization for Research and Treatment of Cancer/Mycoses Study Group consensus definitions, by direct detection of fungal volatile metabolites

SUBMITTER: Koo S 

PROVIDER: S-EPMC4311178 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature