A one-pot multistep cyclization yielding thiadiazoloimidazole derivatives.

ABSTRACT: A versatile synthetic procedure is described to prepare the benzimidazole-fused 1,2,4-thiadiazoles 2a-c via a methanesulfonyl chloride initiated multistep cyclization involving the intramolecular reaction of an in-situ generated carbodiimide with a thiourea unit. The structure of the intricate heterocycle 2a was confirmed by single-crystal X-ray analysis and its mechanism of formation supported by DFT computations.

SUBMITTER: Samanta D 

PROVIDER: S-EPMC4311674 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature