Depression, coronary artery disease, and physical activity: how much exercise is enough?

ABSTRACT:

Purpose

The mechanisms by which depressive symptoms negatively affect clinical outcomes in patients with coronary artery disease (CAD) remain poorly understood. Previous interventions that have attempted to treat depressive symptoms in patients with CAD to improve their clinical outcomes have been disappointing. Our objectives were, among a cohort of CAD patients, to evaluate the impact of depressive symptoms over time, controlling for comorbidity, in determining both successful long-term lifestyle change (ie, increased physical activity), and cardiovascular morbidity and mortality outcomes. In addition, we examined the impact of physical activity changes over time on 2 known mediators of cardiovascular morbidity: parasympathetic tone and inflammation.

Methods

Clinical data

SUBMITTER: Peterson JC 

PROVIDER: S-EPMC4311731 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature