Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile.

ABSTRACT:

Objectives

The present study evaluates the effects of a 6-month treatment with an ACE-inhibitor (ie, fosinopril) on serum concentrations of total IGF-1 and IGF binding protein (IGFBP)-3 in older adults at high risk for cardiovascular disease.

Design

Data are from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study, a double-blind, crossover, randomized, placebo-controlled trial.

Setting

Participants were recruited from the communities of Winston Salem, NC, and Greensboro, NC.

Participants

Subjects > or = 55 years old with high cardiovascular disease risk profile.

Intervention

The intervention consisted of 6-month administration of fosinopril vs. placebo.

Measurements

Serum concentrations of tot

SUBMITTER: Giovannini S 

PROVIDER: S-EPMC4311891 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature