Discovery of new candidate genes related to brain development using protein interaction information.

ABSTRACT: Human brain development is a dramatic process composed of a series of complex and fine-tuned spatiotemporal gene expressions. A good comprehension of this process can assist us in developing the potential of our brain. However, we have only limited knowledge about the genes and gene functions that are involved in this biological process. Therefore, a substantial demand remains to discover new brain development-related genes and identify their biological functions. In this study, we aimed to discover new brain-development related genes by building a computational method. We referred to a series of computational methods used to discover new disease-related genes and developed a similar method. In this method, the shortest path algorithm was executed on a weighted graph that was constructed u

SUBMITTER: Chen L 

PROVIDER: S-EPMC4311913 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature