Secondary primary malignancy risk among patients with esophageal cancer in Taiwan: a nationwide population-based study.

ABSTRACT:

Background

To evaluate the risk and sites of metachronous secondary primary malignancies (SPMs) among patients with esophageal cancer.

Methods

Newly diagnosed esophageal cancer patients between 1997 and 2011 were recruited. To avoid surveillance bias, SPMs that developed within one year were excluded. Standardized incidence ratios (SIRs) of metachronous SPMs in these patients were calculated by comparing to the cancer incidence in the general population. Risk factors for SPM development, included age, sex, comorbidities and cancer-related treatments, were estimated by Cox proportional hazards models.

Results

During the 15-year study period, 870 SPMs developed among 18,026 esophageal cancer patients, with a follow-up of 27,056 person-years. The SIR for all cancers was

SUBMITTER: Chen SC 

PROVIDER: S-EPMC4312084 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature