Glutamate, GABA, and glutamine are synchronously upregulated in the mouse lateral septum during the postpartum period.

ABSTRACT: Dramatic structural and functional remodeling occurs in the postpartum brain for the establishment of maternal care, which is essential for the growth and development of young offspring. Glutamate and GABA signaling are critically important in modulating multiple behavioral performances. Large scale signaling changes occur in the postpartum brain, but it is still not clear to what extent the neurotransmitters glutamate and GABA change and whether the ratio of glutamate/GABA remains balanced. In this study, we examined the glutamate/GABA-glutamine cycle in the lateral septum (LS) of postpartum female mice. In postpartum females (relative to virgins), tissue levels of glutamate and GABA were elevated in LS and increased mRNA was found for the respective enzymes producing glutamate and GABA,

SUBMITTER: Zhao C 

PROVIDER: S-EPMC4312212 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature