Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording.

ABSTRACT: Penetrating intracortical electrode arrays that record brain activity longitudinally are powerful tools for basic neuroscience research and emerging clinical applications. However, regardless of the technology used, signals recorded by these electrodes degrade over time. The failure mechanisms of these electrodes are understood to be a complex combination of the biological reactive tissue response and material failure of the device over time. While mechanical mismatch between the brain tissue and implanted neural electrodes have been studied as a source of chronic inflammation and performance degradation, the electrode failure caused by mechanical mismatch between different material properties and different structural components within a device have remained poorly characterized. Using Fin

SUBMITTER: Kozai TD 

PROVIDER: S-EPMC4312222 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature