Validation of secondary data sources to identify Parkinson disease against clinical diagnostic criteria.

ABSTRACT: Parkinson disease (PD) is the second most common neurodegenerative disorder. Its diagnosis relies solely on a clinical examination and is not straightforward because no diagnostic test exists. Large, population-based, prospective cohort studies designed to examine other outcomes that are more common than PD might provide cost-efficient alternatives for studying the disease. However, most cohort studies have not implemented rigorous systematic screening for PD. A majority of epidemiologic studies that utilize population-based prospective designs rely on secondary data sources to identify PD cases. Direct validation of these secondary sources against clinical diagnostic criteria is lacking. The Framingham Heart Study has prospectively screened and evaluated participants for PD based on clini

SUBMITTER: Jain S 

PROVIDER: S-EPMC4312428 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature