DNA methylation patterns in newborns exposed to tobacco in utero.

ABSTRACT:

Background

Maternal smoking during pregnancy is a major risk factor for adverse health outcomes. The main objective of the study was to assess the impact of in utero tobacco exposure on DNA methylation in children born at term with appropriate weight at birth.

Methods

Twenty mother-newborn dyads, after uncomplicated pregnancies, in the absence of perinatal illness were included. All mothers were healthy with no cardiovascular risk factors, except for the associated risks among those mothers who smoked. Umbilical cord blood and maternal peripheral venous blood were collected and an epigenome-wide association study was performed using a 450 K epigenome-wide scan (Illumina Infinium HumanMethylation 450BeadChip) with adjustment to normalize the DNA methylation for data cell vari

SUBMITTER: Ivorra C 

PROVIDER: S-EPMC4312439 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature