Impact of a high-fat meal on assessment of clopidogrel-induced platelet inhibition in healthy subjects.

ABSTRACT:

Background

Ideal conditions for platelet reactivity testing are critical for optimal selection of a P2Y12 inhibitor. Data are inconsistent regarding the impact of high-fat meals on test assessment.

Methods

Participants included 12 healthy subjects not taking antiplatelet drugs after a 12-hour fast. After baseline assessment, subjects were given a 600 mg dose of clopidogrel. Four hours later, maximum platelet inhibition was tested in the fasting state by light transmission aggregometry (LTA), VerifyNow P2Y12, vasodilator-stimulated phosphoprotein (VASP), and whole blood aggregometry (WBA). Subjects were then provided a high-fat meal, and platelet function was evaluated two hours later. Change in measured platelet aggregation by LTA was the primary endpoint of the study. The W

SUBMITTER: Dobesh PP 

PROVIDER: S-EPMC4312467 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature