Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein.

ABSTRACT: Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.

SUBMITTER: Heimer BW 

PROVIDER: S-EPMC4312478 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature