Serum urate levels and the risk of hip fractures: data from the Cardiovascular Health Study.

ABSTRACT:

Purpose

Uric acid inhibits vitamin D activation experimentally and higher serum urate levels are associated with higher parathyroid hormone levels in humans suggesting a link between uric acid and bone health. We hypothesized that hyperuricemia may increase the risk of fractures in older adults.

Methods

1963 men and 2729 women ≥65 years of age who participated in the Cardiovascular Health Study and had baseline serum urate levels were included in the study. The primary outcome was incident hip fracture, assessed prospectively through June, 2008 by inpatient and outpatient records. The analysis was stratified by sex a priori.

Results

There was a U-shaped relationship between serum urate levels and hip fractures in men. Men in the lowest and the highest urate quartiles

SUBMITTER: Mehta T 

PROVIDER: S-EPMC4312534 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature