Heterosexual HIV-1 infectiousness and antiretroviral use: systematic review of prospective studies of discordant couples.

ABSTRACT:

Background

Recent studies have estimated the reduction in HIV-1 infectiousness with antiretroviral therapy (ART), but high-quality studies such as randomized controlled trials, accompanied by rigorous adherence counseling, are likely to overestimate the effectiveness of treatment-as-prevention in real-life settings.

Methods

We attempted to summarize the effect of ART on HIV transmission by undertaking a systematic review and meta-analysis of HIV-1 infectiousness per heterosexual partnership (incidence rate and cumulative incidence over study follow-up) estimated from prospective studies of discordant couples. We used random-effects Poisson regression models to obtain summary estimates. When possible, the analyses were further stratified by direction of transmission (man-to-w

SUBMITTER: Baggaley RF 

PROVIDER: S-EPMC4312663 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature