Cognitive, medical, and neuroimaging characteristics of attenuated mucopolysaccharidosis type II.

ABSTRACT:

Unlabelled

The phenotype of attenuated mucopolysaccharidosis type II (MPS II), also called Hunter syndrome, has not been previously studied in systematic manner. In contrast to the "severe" phenotype, the "attenuated" phenotype does not present with behavioral or cognitive impairment; however, the presence of mild behavior and cognitive impairment that might impact long-term functional outcomes is unknown. Previously, significant MRI abnormalities have been found in MPS II. Recent evidence suggests white matter abnormalities in many MPS disorders.

Methods

As the initial cross-sectional analysis of a longitudinal study, we studied the association of brain volumes and somatic disease burden with neuropsychological outcomes, including measures of intelligence, memory, and atten

SUBMITTER: Yund B 

PROVIDER: S-EPMC4312717 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature