Interneurons are necessary for coordinated activity during reversal learning in orbitofrontal cortex.

ABSTRACT:

Background

Cerebral cortical gamma-aminobutyric acidergic interneuron dysfunction is hypothesized to lead to cognitive deficits comorbid with human neuropsychiatric disorders, including schizophrenia, autism, and epilepsy. We have previously shown that mice that harbor mutations in the Plaur gene, which is associated with schizophrenia, have deficits in frontal cortical parvalbumin-expressing interneurons. Plaur mice have impaired reversal learning, similar to deficits observed in patients with schizophrenia.

Methods

We examined the role of parvalbumin interneurons in orbitofrontal cortex during reversal learning by recording single unit activity from 180 control and 224 Plaur mouse neurons during a serial reversal task. Neural activity was analyzed during correct and incorr

SUBMITTER: Bissonette GB 

PROVIDER: S-EPMC4312743 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature