Ontology highlight
ABSTRACT:
SUBMITTER: Vidanapathirana AK
PROVIDER: S-EPMC4312756 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Reproductive toxicology (Elmsford, N.Y.) 20140801
Pregnancy is a unique physiological state, in which C60 fullerene is reported to be distributed in both maternal and fetal tissues. Tissue distribution of C60 differs between pregnant and non-pregnant states, presumably due to functional changes in vasculature during pregnancy. We hypothesized that polyvinylpyrrolidone (PVP) formulated C60 (C60/PVP) increases vascular tissue contractility during pregnancy by increasing Rho-kinase activity. C60/PVP was administered intravenously to pregnant and n ...[more]