Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients.

ABSTRACT: Acinetobacter baumannii has emerged as one of the leading pathogens causing hospital-acquired infection. The success of A. baumannii as a pathogen has to a large extent been attributed to its capacity to remodel its genome. Several major epidemic clonal complexes of A. baumannii spread across different health care facilities around the world, each of which contains a subset of diversified strains. However, little is known about the population dynamics during colonization of A. baumannii within hosts. Here, whole-genome sequencing was used to analyze population dynamics of A. baumannii strains isolated from a group of patients at different time points as well as from different sites of a particular patient. Seven out of nine of the sampled A. baumannii strains belonged to the international

SUBMITTER: Wen H 

PROVIDER: S-EPMC4313138 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature