Microevolution of Burkholderia pseudomallei during an acute infection.

ABSTRACT: We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.

SUBMITTER: Limmathurotsakul D 

PROVIDER: S-EPMC4313173 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature