Major intercontinentally distributed sequence types of Kingella kingae and development of a rapid molecular typing tool.

ABSTRACT: Although Kingella kingae is the most common etiology of osteoarticular infections in young children, is a frequent cause of bacteremia in those younger than 4 years, and has been involved in clusters of invasive infections among daycare center attendees, the population structure of the species has not been systematically studied. Using multilocus sequence typing, we investigated the genetic diversity of the largest intercontinental collection of K. kingae strains to date. To facilitate typing of bacterial isolates, we developed a novel genotyping tool that targets the DNA uptake sequence (DUS). Among 324 strains isolated from asymptomatic carriers and patients from Israel, Europe, North America, and Australia with various invasive forms of the disease from 1960 to 2013, we identified 64 se

SUBMITTER: Basmaci R 

PROVIDER: S-EPMC4313220 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature