Quantitative matrix-assisted laser desorption ionization-time of flight mass spectrometry for rapid resistance detection.

ABSTRACT: Antibiotic resistance in Gram-negative microorganisms is an increasing health care problem. The rapid detection of such resistance is crucial for starting an early specific therapy and to enable initiation of the required hygiene measures. With continued emphasis on reducing the cost of laboratory testing, only economical/low-cost approaches have a chance of being implemented. During recent years, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been developed to be a standard method in microbiology laboratories for the rapid and cost-efficient identification of microorganisms. Extending the usage of MALDI-TOF MS in the clinical microbiology laboratory to the area of resistance testing is an attractive option. Quantitative MALDI-TOF MS using a

SUBMITTER: Lange C 

PROVIDER: S-EPMC4313279 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature