Genotypic characterization of canine coronaviruses associated with fatal canine neonatal enteritis in the United States.

ABSTRACT: Emerging canine coronavirus (CCoV) variants that are associated with systemic infections have been reported in the European Union; however, CCoV-associated disease in the United States is incompletely characterized. The purpose of this study was to correlate the clinicopathological findings and viral antigen distribution with the genotypic characteristics of CCoV in 11 puppies from nine premises in five states that were submitted for diagnostic investigation at Cornell University between 2008 and 2013. CCoV antigen was found in epithelial cells of small intestinal villi in all puppies and the colon in 2 of the 10 puppies where colon specimens were available. No evidence of systemic CCoV infection was found. Comparative sequence analyses of viral RNA extracted from intestinal tissues reveal

SUBMITTER: Licitra BN 

PROVIDER: S-EPMC4313292 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature