Novel Perfused Compression Bioreactor System as an in vitro Model to Investigate Fracture Healing.

ABSTRACT: Secondary bone fracture healing is a physiological process that leads to functional tissue regeneration via endochondral bone formation. In vivo studies have demonstrated that early mobilization and the application of mechanical loads enhances the process of fracture healing. However, the influence of specific mechanical stimuli and particular effects during specific phases of fracture healing remain to be elucidated. In this work, we have developed and provided proof-of-concept of an in vitro human organotypic model of physiological loading of a cartilage callus, based on a novel perfused compression bioreactor (PCB) system. We then used the fracture callus model to investigate the regulatory role of dynamic mechanical loading. Our findings provide a proof-of-principle that dynamic mechan

SUBMITTER: Hoffmann W 

PROVIDER: S-EPMC4313709 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature