Partner-based adherence intervention for second-line antiretroviral therapy (ACTG A5234): a multinational randomised trial.

ABSTRACT:

Background

Adherence is key to the success of antiretroviral therapy. Enhanced partner support might benefit patients with previous treatment failure. We aimed to assess whether an enhanced partner-based support intervention with modified directly observed therapy would improve outcomes with second-line therapy in HIV-infected patients for whom first-line therapy had failed.

Methods

We did a multicentre, international, randomised clinical trial at nine sites in Botswana, Brazil, Haiti, Peru, South Africa, Uganda, Zambia, and Zimbabwe. Participants aged 18 years or older for whom first-line therapy had failed, with HIV RNA concentrations greater than 1000 copies per mL and with a willing partner, were randomly assigned (1:1), via computer-generated randomisation, to receive p

SUBMITTER: Gross R 

PROVIDER: S-EPMC4313760 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature