Antihypertensive treatment and secondary prevention of cardiovascular disease events among persons without hypertension: a meta-analysis.

ABSTRACT:

Context

Cardiovascular disease (CVD) risk increases beginning at systolic blood pressure levels of 115 mm Hg. Use of antihypertensive medications among patients with a history of CVD or diabetes and without hypertension has been debated.

Objective

To evaluate the effect of antihypertensive treatment on secondary prevention of CVD events and all-cause mortality among persons without clinically defined hypertension.

Data sources

Meta-analysis with systematic search of MEDLINE (1950 to week 3 of January 2011), EMBASE, and the Cochrane Collaboration Central Register of Controlled Clinical Trials and manual examination of references in selected articles and studies.

Study selection

From 874 potentially relevant publications, 25 trials that fulfilled the predetermine

SUBMITTER: Thompson AM 

PROVIDER: S-EPMC4313888 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature