Nucleus pulposus cells derived IGF-1 and MCP-1 enhance osteoclastogenesis and vertebrae disruption in lumbar disc herniation.

ABSTRACT:

Study design

Chronic strained lumbar disc herniation (LDH) cases were classified into bulging LDH, herniated LDH and prolapse LDH types according to imaging examination, and vertebrae disruptions were evaluated. Cytokines derived from the nucleus pulposus cells were detected, and their effects on osteoclastogenesis, as well as the mechanisms involved, were studied via an in vitro osteoclast differentiation system.

Objective

To clarify the mechanisms of lumbar vertebrae resorption induced by lumbar herniation.

Summary and background data

Chronic strained lumbar disc herniation induced vertebrae erosion exacerbates quality of patients' life and clinical outcome. Although nucleus pulposus cells derived cytokines were reported to play an important role in this pathogenesi

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC4313999 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature