Regional ventilation changes in severe asthma after bronchial thermoplasty with (3)He MR imaging and CT.

ABSTRACT:

Purpose

To quantify regional lung ventilation in healthy volunteers and patients with severe asthma (both before and after thermoplasty) by using a combination of helium 3 ((3)He) magnetic resonance (MR) imaging and computed tomography (CT), with the intention of developing more effective image-guided treatments for obstructive lung diseases.

Materials and methods

With approval of the local institutional review board, informed consent, and an Investigational New Drug Exemption, six healthy volunteers and 10 patients with severe asthma were imaged in compliance with HIPAA regulations by using both multidetector CT and (3)He MR imaging. Individual bronchopulmonary segments were labeled voxel by voxel from the CT images and then registered to the (3)He MR images by using custom

SUBMITTER: Thomen RP 

PROVIDER: S-EPMC4314114 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature